This meta-analysis was designed to compare the efficacy and safety of gemcitabine-based regimens for the treatment advanced breast cancer ABC. Altogether 15 studies involving ABC patients were retrieved for analysis. These findings indicate that gemcitabine combination regimens could serve as a promising regimen for ABC patients, though increased hematologic toxicity should be considered with caution.
Please take this quick survey to tell us about what happens after you publish a paper. The aim of the study was to evaluate the efficacy and tolerability of single-agent gemcitabine in the maintenance treatment of histologically confirmed metastatic breast cancer cases. Patients in the maintenance therapy group received gemcitabine therapy until 6 cycles, disease progression or adverse effect intolerance.
Heinemann med3. Gemcitabine is a pyrimidine antimetabolite which has shown activity in metastatic breast cancer both as a single agent, but also in various combination regimens. It is characterized by a unique mechanism of action which includes cytotoxic self-potentiation, masked DNA chain termination and potent inhibition of DNA repair.
Approximatelynew cases of breast cancer are diagnosed annually in the United States. Patients with locally advanced breast cancer have cancer that has spread to nearby lymph nodes or the chest wall. Patients with metastatic breast cancer have cancer that has spread to distant sites in the body.
This protocol is based on limited evidence; please refer to the evidence section of this protocol for more information. Check for clinical trials in this patient group. Link to Australian Clinical Trials website.
This phase II study evaluated the efficacy and safety of gemcitabine G plus paclitaxel T as first-line therapy in recurrent or metastatic breast cancer. Forty patients, 39 metastatic breast cancer and 1 locally-advanced disease, were enrolled. Their median age was
Please take this quick survey to tell us about what happens after you publish a paper. Breast Cancer Research and Treatment. A phase II study was performed to investigate the efficacy and tolerability of gemcitabine as third-line chemotherapy for patients with metastatic breast cancer, previously treated with both an anthracycline - and taxane-containing regimen.
Gemcitabine is a chemotherapy drug used to treat breast cancer. Back to top. Gemcitabine is usually used in combination with another chemotherapy drug, either carboplatin or paclitaxel Taxol.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality in females worldwide 1. While significant treatment advances have been made, all patients face the risk of disease recurrence, which is the main cause of death from breast cancer 2. In recent years, studies on cancer development and recurrence have been influenced by side population SP cells 3. SP cells are a small subpopulation of cells with enriched stem cell activity 4.