Study record managers: refer to the Data Element Definitions if submitting registration or results information. This is a multi-center, randomized, double-blind, placebo-controlled, parallel-group study. A sufficient number of patients will be screened to obtain approximately patients randomized to the double-blind portion of the study.
Medically reviewed by Drugs. Last updated on Oct 29, The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2, respectively.
Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy. Prevention of nausea and vomiting associated with radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. Prevention of post-op nausea and vomiting.
This leaflet answers some common questions about Zofran Syrup. It does not contain all of the available information. All medicines have risks and benefits.
To get the latest experience from our website, please upgrade your browser. Zofran and Zuplenz are prescription drugs used to treat nausea related to surgeries, cancer treatment and pregnancy. The drug has been prescribed for off-label uses despite the fact that there is a risk of side effects like serotonin syndrome and pregnancy risks.
Drug information provided by: IBM Micromedex. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
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Risk factors for development of PONV include female gender, history of motion sickness or PONV, type and duration of surgery and use of postoperative opioids. Development of PONV can increase discomfort, dissatisfaction, length of stay and overall health care costs for patients. Ondansetron is a selective 5-HT3-receptor antagonist that blocks serotonin peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. The onset of action is about 30 minutes with metabolism occurring in the liver.