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Muscle wasting is a serious complication of various clinical conditions that significantly worsens the prognosis of the illnesses. Clinically relevant models of muscle wasting are essential for understanding its pathogenesis and for selective preclinical testing of potential therapeutic agents. The data presented here indicate that muscle wasting has been well characterized in rat models of sepsis endotoxaemia, and caecal ligation and puncturein rat models of chronic renal failure partial nephrectomyin animal models of intensive care unit patients corticosteroid treatment combined with peripheral denervation or with administration of neuromuscular blocking drugs and in murine and rat models of cancer tumour cell transplantation. There is a need to explore genetically engineered mouse models of cancer.

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Mark Jenkins. Roger Hawkins, a member of the Muscle Shoals Rhythm Section also known as the Swampersis just one among the many musicians captured in this documentary about the famous town. Magnolia Pictures hide caption.

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